Heidelberg 01 July 2019.
The research group at the David J Apple International Laboratory for Ocular Pathology published its latest findings in this month’s edition of the renowned Journal of Cataract & Refractive Surgery.
The impact of glistenings on the optical quality of a hydrophobic acrylic intraocular lens
Jan N. Weindler, Grzegorz Łabuz, Timur M. Yildirim, Tamer Tandogan, Ramin Khoramnia, Gerd U. Auffarth.
Volume 45, Issue 7, 2019, Pages 1020-1025, ISSN 0886-3350, https://doi.org/10.1016/j.jcrs.2019.01.025.(http://www.sciencedirect.com/science/article/pii/S0886335019300598)
Dr Jan Weidler.“We used an established ageing method to induce microvacuoles in thirty-eight hydrophobic acrylic
Dr Grzegorz Łabuz, “We found Glistenings in all the IOLs. The mean glistening numbers ± SD (MV/mm2) in grades 1 through to 4 were 74 ± 12.7, 142 ± 22.2, 297 ± 76.2, and 1509 ± 311.9, respectively. The mean glistening sizes in grades 1 through 4 were 13.28 ± 3.85 μm, 15.88 ± 2.08 μm, 16.85 ± 3.23 μm, and 15.27 ± 2.25 μm, respectively. “
Statistical analysis showed that grades 1 through 3 did not change the optical quality. In grade 4, the MTF and the Strehl ratio were significantly affected. Dr
Prof. Gerd Auffarth, the research leader at the D J Apple Lab, commented that this level of detailed research on IOL optics showed how the Lab had changed since coming to Heidelberg. “When I worked with David Apple at the Lab in Charleston, we did important work in describing the morphological changes that clinicians were starting to seeing in post-implantation hydrophobic IOLs. But this was largely a descriptive observation of clinical images of IOLs in the eye and of explanted IOLs. Then we did not study the optical quality. Now, twenty-five years later, in Heidelberg, we are getting down to the details of how water vacuoles in the IOL polymer have an impact on the quality of the lens.”
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